Contains correspondence by Kane written between 1857 and 1894. Most of the letters are to members of the Kane family, and include information on family activities and travels. Also includes correspondence related to Kane's research on Silas Freeman.

Contains letters, programs, and other material by Kane. The correspondence is primarily with family members, and deals with concerns. Also includes materials related to her work with the Women's Christian Temperance Union. Materials date from between 1830 and 1909.

Contains letters, notes, clippings, and other materials relating to Kane's visit to Utah in 1872. Includes information on their travels, conditions in Utah, and the publication of her account in the book Twelve Mormon Homes. Materials date from between 1860 and 1877.

Contains correspondence, a journal, and published articles by Kane. Most of the unpublished materials deal with the Kane family and his personal interests, while the articles relate to his medical practice. Materials date from between 1872 and 1930.

Contains journals, correspondence, ephemera, and other materials by Kane. Includes information on her life and activities, including her medical studies and practice. Also includes information on her relationships and interactions with other members of the Kane family. Materials date from between 1870 and 1894.

Contains materials related to the life and activities of Kane. These consist primarily of a series of composition books and two letters. The composition books contain mostly letters written by Harriet to her mother, father, and others, but later volumes include medical notes. The letters concern family matters, and a purchase made by a friend on Harriet's behalf. Materials date between 1870 and 1891.

Contains genealogical information, biographies, correspondence, receipts, and other materials related to Kane's ancestors and other members of the extended Kane family. Items document personal activities, family relations, business ventures and transactions, and other topics. Materials date from between 1773 and 1916.

Contains correspondence, bills, receipts, statements, ledgers, and other material relating to the Kane family's business activities. Includes information on the Kane Plumbing Company, Kane Gas Light & Heating, Kane Summit Hospital, and Kushequa Brick Company, as well as other enterprises. Materials date from between 1886 and 1943.

Contains correspondence by members of the Kane family with various organizations, including letters from the Library of Congress inviting the family to donate the papers of Elisha Kent Kane. Materials date from between approximately 1958 and 1965.

Contains correspondence, clippings, maps, and financial records relating to core family business activities, including the development of western Pennsylvania, the history of town of Kane, railroad investments, and other businesses. Materials date from between 1844 and 1943.