The Thomas L. Kane (1822-1883) and Elizabeth Kane (1836-1909) family was a prominent family from Pennsylvania, and friends of members to The Church of Jesus Christ of Latter-day Saints in the 19th Century.

The Kane family was a prominent family of politicians, lawyers, and doctors in Pennsylvania. Thomas L. Kane (1822-1883) was born in Philadelphia to John K. Kane (1795-1858), judge and politician in the city. In 1853, Thomas married Elizabeth Dennistown Wood (1836-1909), and they had four children: Harriet, Elisha, Evan, and William, who later changed his name to Thomas after the death of his father. Thomas L. Kane was a friend of Brigham Young and the Mormons and helped facilitate their migration to Utah, and forged a compromise that kept the Utah War of 1857-58 from escalating to bloodshed. Elizabeth Kane wrote a book on her visit to Utah and interaction with the Mormons during the winter of 1872-73, titled "Twelve Mormon Homes." Following the Civil War, the Kane family moved to western Pennsylvania to found the town of Kane, Pennsylvania.