Contains a letter, several notes, picture cards, and a botanical pressing found within printed works in the Kane family collection. The letter is concerns a trial and injustice in the life of Thomas L. Kane and is signed by his aunt. The notes include copied scriptural and lyrical passages, as well as notes on a book concerning genealogy. The picture cards depict religious scenes. Materials date from 1849 to the late 19th century.

Contains correspondence, notes, daybooks, and other materials relating to the Kane family's involvement in railroad development in McKean County, including the Philadelphia and Erie Railroad, the Kinzua Viaduct Railroad, the New York and Erie Railroad, and the Pennsylvania Railroad Company. Materials date from between 1856 and 1932.

Contains deeds, programs, letters, poems, and other items related to Kane and the Kane family. Includes genealogical and financial information. Materials date from between 1690 and 1912.

Contains notes, letters, and other materials collected by Kane on the Indians of Utah, Indian sign language, and westward expansion. Materials date from between 1845 and 1872.

Contains material relating to Kane's related activities connected with the development of the American West. Includes information on his lobbying for appointment to territorial governorships, his interests in Alaska and Mexico, Western railroad development, and his correspondence with a variety of state and national politicians.