Contains letters, notes, pamphlets, clippings, and other materials by Kane. Materials document his activities, including his work at the hospital and his family relationships. Materials date from between 1869 and 1929.

Contains letters, notes, clippings, and other materials relating to Kane's visit to Utah in 1872. Includes information on their travels, conditions in Utah, and the publication of her account in the book Twelve Mormon Homes. Materials date from between 1860 and 1877.

Contains deeds, programs, letters, poems, and other items related to Kane and the Kane family. Includes genealogical and financial information. Materials date from between 1690 and 1912.

Contains notes, letters, and other materials collected by Kane on the Indians of Utah, Indian sign language, and westward expansion. Materials date from between 1845 and 1872.

Contains material relating to Kane's related activities connected with the development of the American West. Includes information on his lobbying for appointment to territorial governorships, his interests in Alaska and Mexico, Western railroad development, and his correspondence with a variety of state and national politicians.