Contains letters, notes, pamphlets, clippings, and other materials by Kane. Materials document his activities, including his work at the hospital and his family relationships. Materials date from between 1869 and 1929.

Contains letters, notes, clippings, and other materials relating to Kane's visit to Utah in 1872. Includes information on their travels, conditions in Utah, and the publication of her account in the book Twelve Mormon Homes. Materials date from between 1860 and 1877.

Contains lithographs, clippings, notes, and other materials relating to the Kane family activities. Materials date from between 1815 and 1931.

Contains journals and notebooks belonging to Kane, as well as manuscripts, letters, passports, and other materials. Items include lists of Kane's everyday dealings, his poetic and philosophical writings, his last will and testament, and his obituary. Materials date between 1839 and 1884.