Contains typescripts, articles, notes, pamphlets, and correspondence gathered by Kane on the history of the Kane family. Materials date from between 1851 and 1982.

Contains clippings, notes, and other materials gathered by Kane relating to his research on Elisha Kent Kane (1856-1935). Materials date from between 1907 and 1961.

Contains correspondence, articles, notes, clippings, and other research materials gathered by Kane in the course of his family history research. Includes information on various family members, their activities, and accomplishments. Materials date from between 1830 and 1982.

Contains correspondence, biographical sketches, clippings, and notes gathered by Kane on the life of Thomas L. Kane (1822-1883). Materials date from between 1846 and 1977.

Contains two copies of Kane's two-volume history of the settlement of Kane, Pennsylvania. One is a hand-written manuscript, while the other is a carbon-copy of a typeset edition. The book is about the founding of Kane, Pennsylvania by Kane and her husband in the mid-1800s. It mostly relates personal experiences relating to her time there, and is dedicated to her grandchildren. Items date from about 1868.

Contains materials related to the life and activites of Elizabeth Wood Kane. It is composed primarily of a series of journals, several bound books, and a wide variety of papers and newspaper clippings. Subjects include records of daily life, domestic tasks, family matters, the settlement of Kane, Pennsylvania, and Elizabeth's activities as a medical doctor. Materials date between 1868 and 1907.

Contains a soft-bound recipe book belonging to Kane, and various newspaper clippings and notes found within it. The recipe book contains not only recipes, but also instructions detailing how to perform other domestic tasks like crocheting. The newspaper clippings and notes are mostly recipes, but also include articles and advertisements concerning domestic subjects. All materials are undated.

Contains materials related to the life and activities of Kane. These consist primarily of a series of composition books and two letters. The composition books contain mostly letters written by Harriet to her mother, father, and others, but later volumes include medical notes. The letters concern family matters, and a purchase made by a friend on Harriet's behalf. Materials date between 1870 and 1891.

Contains correspondence, bills, receipts, statements, ledgers, and other material relating to the Kane family's business activities. Includes information on the Kane Plumbing Company, Kane Gas Light & Heating, Kane Summit Hospital, and Kushequa Brick Company, as well as other enterprises. Materials date from between 1886 and 1943.

Contains correspondence, clippings, maps, and financial records relating to core family business activities, including the development of western Pennsylvania, the history of town of Kane, railroad investments, and other businesses. Materials date from between 1844 and 1943.