Contains two copies of Kane's two-volume history of the settlement of Kane, Pennsylvania. One is a hand-written manuscript, while the other is a carbon-copy of a typeset edition. The book is about the founding of Kane, Pennsylvania by Kane and her husband in the mid-1800s. It mostly relates personal experiences relating to her time there, and is dedicated to her grandchildren. Items date from about 1868.

Contains materials related to the life and activites of Elizabeth Wood Kane. It is composed primarily of a series of journals, several bound books, and a wide variety of papers and newspaper clippings. Subjects include records of daily life, domestic tasks, family matters, the settlement of Kane, Pennsylvania, and Elizabeth's activities as a medical doctor. Materials date between 1868 and 1907.

Contains a soft-bound recipe book belonging to Kane, and various newspaper clippings and notes found within it. The recipe book contains not only recipes, but also instructions detailing how to perform other domestic tasks like crocheting. The newspaper clippings and notes are mostly recipes, but also include articles and advertisements concerning domestic subjects. All materials are undated.