Jesse Nathaniel Smith (1834-1906) was a Mormon pioneer and missionary. He served a mission for the Church of Jesus Christ of Latter-day Saints to Scandinavia.

Jesse Nathaniel Smith was born to Silas and Mary Aiken Smith in Stockholm, New York. His father died when Jesse was four years old and the Smith family was living in Illinois. When the Latter-day Saint Church migrated from Illinois to Salt Lake City, the teenage Jesse helped his mother cross the plains. Upon arriving in Utah, Jesse was sent to help settle the town of Parowan. In 1861, Jesse embarked on the Scandinavian Mission for the Latter-day Saint Church. His first assignment was in Denmark. He later served as president of this mission in 1868. Living in Utah, Jesse Smith held multiple civil positions and assisted with Indian Wars. He also helped to settle colonies in Arizona and New Mexico. A practicer of plural marriage, Jesse married five women and had forty-four children. Jesse Smith died in Snowflake, Arizona at the age of seventy-two.