Contains manuscripts, drafts, and source materials related to Kane's history of Kane, Pennsylvania. Includes information on the Kane family's role in settlement and autobiographical writings. Materials date from between approximately 1866 and 1896.

Contains letters, telegraphs, newspaper clippings, and other materials related to the formation of the 42nd Pennsylvania Infantry Regiment. Contains information on his role in the unit, and conflicts with Charles J. Biddle. Materials date from between 1861 and 1906.

Contains correspondence, notes, clippings, and other material related to Kane's wartime service. Also contains additional materials related to the war without clear ties to Kane. Materials date from between 1861 and 1883.

Contains correspondence, maps, notes, financial records, clippings, and other materials relating to the McKean and Elk Land and Improvement Company. Includes information on Thomas L. Kane's work as an agent for the company, progress being made in developing the region, financial concerns of the company, and legal actions surrounding the property. Materials date from between 1844 and 1926.

Contains correspondence, notes, daybooks, and other materials relating to the Kane family's involvement in railroad development in McKean County, including the Philadelphia and Erie Railroad, the Kinzua Viaduct Railroad, the New York and Erie Railroad, and the Pennsylvania Railroad Company. Materials date from between 1856 and 1932.

Contains correspondence, insurance policies, and other documents related to Kane's business dealings. Includes information on land sales, his service on various boards, and other matters. Materials date from between 1846 and 1884.