Contains artifacts found in the Kane family collection. These consist of two linens with the initials E.D.K. embroidered in them, and a silver creamer with the same initials. Materials are undated.

Contains two copies of Kane's two-volume history of the settlement of Kane, Pennsylvania. One is a hand-written manuscript, while the other is a carbon-copy of a typeset edition. The book is about the founding of Kane, Pennsylvania by Kane and her husband in the mid-1800s. It mostly relates personal experiences relating to her time there, and is dedicated to her grandchildren. Items date from about 1868.

Contains materials related to the life and activites of Elizabeth Wood Kane. It is composed primarily of a series of journals, several bound books, and a wide variety of papers and newspaper clippings. Subjects include records of daily life, domestic tasks, family matters, the settlement of Kane, Pennsylvania, and Elizabeth's activities as a medical doctor. Materials date between 1868 and 1907.

Contains photographs found in the pages of Kane's personal journals. The photographs depict people who are presumably Kane family members, and a house. Several of the photographs have deteriorated beyond recognition. Materials are largely undated and unlabeled, but presumably date from the mid-19th century to early-20th century.

Contains a soft-bound recipe book belonging to Kane, and various newspaper clippings and notes found within it. The recipe book contains not only recipes, but also instructions detailing how to perform other domestic tasks like crocheting. The newspaper clippings and notes are mostly recipes, but also include articles and advertisements concerning domestic subjects. All materials are undated.

The Thomas L. and Elizabeth W. Kane Paintings, circa 1860-1865, include one archival series: Paintings, circa 1860-1865.

This collection is a progressional compilation of genealogical information on Thomas L. Kane, his wife Elizabeth Dennistoun Wood Kane, and their ancestors and descendants.