Contains Kane's manuscripts, including her fourteen diaries, beginning in 1853 and ending in 1909, although there are numerous gaps in their coverage. The first nine date before her husband's death, and include accounts of his life. Also includes the papers of her father, William Wood, as well as Kane's mostly unpublished work.

Contains autobiographical and literary writings by Elizabeth Wood Kane. Most of the documents, including travel accounts, focus on her life and experiences. She writes about her husband Thomas L. Kane serving in the Civil War, her experiences with the Mormons in the West, and Also includes family history projects, getting to meet President Ulysses S. Grant, and other family affairs. Materials also include family history writings like the autobiography of her father. Dated 1856-1921.

Contains a manuscript relating Kane's experiences while travelling with her son Evan O'Neill Kane to the State Medical Societies to the Pan-American Congress in 1896. Includes copies of correspondence and published articles. Materials date from between 1896 and 1897.

Materials include a manuscript written by Elizabeth Wood Kane describing Ulysses S. Grant's visit with the Kane family; there are details about their activities, discussions, and her impressions of the presidential party. Many of their conversations were about politics, religion, and race relations. Dated 1869.

Contains manuscripts, drafts, and source materials related to Kane's history of Kane, Pennsylvania. Includes information on the Kane family's role in settlement and autobiographical writings. Materials date from between approximately 1866 and 1896.

Contains pamphlets and manuscripts relating to the Kane family, including information on the Van Rensselaer family and Thomas L. Kane's service during the Civil War. Materials date from around 1898.

Contains correspondence, notes, speeches, and other materials related to Kane's interest in exploration and colonization in Mexico and Alaska. Materials date from between 1868 and 1930.

Contains journals and notebooks belonging to Kane, as well as manuscripts, letters, passports, and other materials. Items include lists of Kane's everyday dealings, his poetic and philosophical writings, his last will and testament, and his obituary. Materials date between 1839 and 1884.

Contains material relating to Kane's related activities connected with the development of the American West. Includes information on his lobbying for appointment to territorial governorships, his interests in Alaska and Mexico, Western railroad development, and his correspondence with a variety of state and national politicians.

Contains the more personal papers of Kane. It includes papers relating to his youth, a large collection of letters he sent home from England and France, his early correspondence with Elizabeth Wood, and their correspondence following their marriage. It also includes his correspondence with Elizabeth's father, William Wood, as well as with other Kane family members. Materials date between 1835 to 1886.